All You Need to Know about Adverse Effects of NMN – Scooptimes

In the last couple of years, NMN supplements have gained much attention from consumers and the scientific community. Although research into this elixir is ongoing, it is purported to have numerous health benefits and anti-aging elements, earning the title ‘fountain of youth.’ NMN may lower heart disease risk, boost eye function, enhance athletic performance, improve metabolic health, and prolong lifespan.

Nonetheless, there are safety concerns regarding NMN since it is a relatively new supplement, and research on its properties, use, and effects is still in its infancy. As a result, some people are reluctant to use the supplement for medicinal and therapeutic purposes. 

Read on to learn about NMN’s safety and potential adverse effects.

NMN’s Safety

You may ask, is NMN safe, and are there any NMN side effects? NMN is safe and well-tolerated for most people. A 2023 research in the Geroscience Journal assessed whether NMN is safe and efficient among healthy middle-aged persons. The findings revealed that NMN doses of up to 900 mg daily were safe with no adverse effects.

Similarly, another research shows that taking up to 1,250mg of NMN daily is well tolerated without undesirable side effects. A 2020 clinical study also showed that NMN doses of 100 to 500 mg were safe. The participants did not report notable changes in their blood pressure, heart rate, oxygen saturation, or sleep quality.

NMN is widely used in clinical treatments and as a dietary supplement to enhance brain and heart health, manage diabetes, improve sleep, and boost workout. When you take NMN, it is converted into NAD, which helps with crucial bodily functions like metabolism, DNA repair, and energy production.

Among the most prominent benefits of NMN are increasing longevity and reversing age-related conditions. You are vulnerable to many diseases as you age due to the naturally declining NAD levels. Taking NMN optimizes NAD levels to reduce age-related conditions and related decline, thus prolonging lifespan and life quality.     

The Adverse Effects of NMN

Although NMN is safe for human use, it may have some mild side effects. A study shows that NMN users may get mild side effects like diarrhea, abdominal pain, and upper respiratory problems. Other potential side effects of NMN include;

  • Headaches
  • Nausea
  • Bloating
  • Itching
  • Sweating
  • Lightheadedness
  • Indigestion

However, most of these side effects are minor and disappear quickly. In addition, the adverse effects are negligible compared to the benefits you get from NMN. But should you experience any of these side effects, it is best if you stop taking the supplements and consult a health provider immediately.

A 2020 study in the Biomolecules Journal contends that high doses of NMN may result in DNA damage, death of embryonic stem cells, decreased SIRT1 activity, and impaired glucose tolerance. 

The kidney, liver, and cells in plasma are the main organs adversely affected by NMN. For example, high NMN doses may result in liver injury and portal fibrosis, as well as decreased insulin sensitivity.

How to Avoid Adverse Effects of NMN  

When buying NMN, ensure you perform your due diligence to promote safety and well-being. Firstly, only buy NMN from reputable vendors whose products are tested by third parties for quality and safety. The vendor should also be certified by professional entities like US Pharmacopeia, which have stringent supplement safety standards.

Secondly, people with allergies should ensure the NMN supplements do not have common allergens like soy, dairy, and gluten. Also, depending on your medical history and current meds, ensure the NMN supplements don’t have ingredients that may cause harmful interactions.

NMN supplements may contain other ingredients like vitamins, herbs, and minerals that interact with other medications. As such, talking to your doctor before adding NMN supplements to your regime is best practice. 

The doctor will clear you to take the supplements and discuss the benefits and risks. Also, they are in a position to identify any potential interactions and advise accordingly.  

Thirdly, watch out for NMN products with meager prices; they may be impure, unsafe, and not third-party tested. Fourthly, adhere to the recommended doses for NMN. Although there’s no predefined upper limit for NMN, it is advisable to avoid large doses to avert adverse health outcomes. 

Stick to the vendor-provided doses or ask your doctor for dosing advice. Research shows doses of between 300 and 1200 mg daily are optimal.   


NMN is a magical elixir with many potential benefits for the heart, brain, eyes, and metabolism. Also, it is an excellent anti-aging and longevity supplement that increases healthspan and lifespan.

The good thing about NMN is that it is safe and well-tolerated in most people with negligible adverse effects. When taken in the recommended dosage and pure form, NMN can enhance your health and wellness!